描述:S-(5'-Adenosyl)-L-methionine (SAM) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases.1,2,3 SAM (tosylate) (SAMe) is a stable salt of SAM that is included in nutritional supplements for oral use.4 SAMe reportedly ameliorates depression, pain associated with osteoarthritis and fibromyalgia, and liver toxicity.5,4,6,7,8