GLY-ASN-HIS-TRP-ALA-VAL-GLY-HI

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试剂描述：

产品名称：GLY-ASN-HIS-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2: GNHWAVGHLM-NH2

产品别名：

CAS号：312306-89-1

英文别名：GLY-ASN-HIS-TRP-ALA-VAL-GLY-HIS-LEU-MET-NH2: GNHWAVGHLM-NH2

分子量：3080.4

分子式：C₁₄₁H₂₀₃N₄₁O₃₈

纯度：

外观：见爱必信官网

保存方法：Store at -20℃

描述：Neuromedin U (NMU) is a neuropeptide first demonstrated to drive smooth muscle contraction.¹ Translated as a 174 amino acid propeptide, NMU is cleaved to different lengths in different animals. It has diverse receptor-mediated roles in vivo, as it regulates feeding, vasoconstriction, nociception, and bone remodeling and contributes to obesity, cancer and septic shock.^2,2 NMU-25 is the active form of NMU in humans. It binds with high affinity to receptors on human left ventricle and coronary artery (K_Ds = 0.26 and 0.11 nM, respectively), eliciting endothelium-independent vasoconstriction.³ NMU-25 also suppresses glucose-stimulated insulin secretion in human islets, and this effect is lost in NMU R165W mutants, resulting in early-onset obesity.⁴

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