CCG-203971,1443437-74-8

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试剂描述：

产品名称：CCG-203971

产品别名：

CAS号：1443437-74-8

英文别名：CCG-203971

分子量：408.9

分子式：C₂₃H₂₁ClN₂O₃

纯度：≥90%

外观：见爱必信官网

保存方法：Store at -20℃

描述：Signaling through small G proteins of the RhoA subfamily, including RhoC, induces actin-regulated cytosolic-to-nuclear translocation of the oncogene product megakaryoblastic leukemia 1 (MKL1), which binds to serum response factor (SRF).¹ The MKL1/SRF complex, in turn, activates the transcription of serum response element (SRE) regulated genes, stimulating cell migration, a process that is central to metastasis.¹ CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC₅₀ = 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.² This compound also inhibits PC-3 cell migration (IC₅₀ = 4.2 μM), as determined by a scratch wound assay.² CCG-203971 causes no cytotoxicity when evaluated by WST-1 assay.² It is well tolerated in normal mice up to doses of 100 mg/kg given intraperitoneally over five days.²

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