(2R)-辛基-α-羟基戊二酸,1391194-67-4

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试剂描述：

产品名称：(2R)-辛基-α-羟基戊二酸

产品别名：

CAS号：1391194-67-4

英文别名：(2R)-辛基-α-羟基戊二酸

分子量：260.3

分子式：C₁₃H₂₄O₅

纯度：≥95%

外观：见爱必信官网

保存方法：Store at -20℃，2 years

描述：α-Hydroxyglutaric acid  is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.^1,2,3 Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate.^4,5 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.^5,6,7 (2R)-Octyl-α-hydroxyglutarate is a cell-permeable derivative of the D-isomer of 2-HG. It has been used to examine the contribution of D-2HG to the oxidative mitochondrial processes of IDH1-mutated cancer cells.⁸

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