β-淀粉样多肽(1-42),107761-42-2

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试剂描述：

产品名称：beta-淀粉样多肽-42

产品别名：Β淀粉样肽-42 (C端多肽); BETA-淀粉样蛋白-42

CAS号：107761-42-2

英文别名：beta-淀粉样多肽-42

分子量：4514.10

分子式：C₂₀₃H₃₁₁N₅₅O₆₀S

纯度：95%

外观：white Lyophilized powder

保存方法：-20 °C，避光，干燥，有效期1年。

描述：Aβ 1-42, 42-residue fragment of amyloid precursor protein, has been found to be a major constituent of the senile plaques formed in the brains of patients with Alzheimer´s disease and late Down´s syndrome. Aβ 1-42 readily forms neurotoxic oligomers at physiological pH. On the other hand, the peptide shows antimicrobial activity. The sequence of H-1368 corresponds to the human, bovine, canine, feline, ovine, guinea pig, and rabbit Aβ42 peptide. The peptide has been used to detect amyloid β-protein multimers in the cerebrospinal fluid of Alzheimer´s disease patients through fluorescence correlation spectroscopy. For detailed descriptions of the preparation of Aβ 1-42 monomers and protofibrils please see the papers of Jan, Hartley, and Lashuel, Stine et al. (2011), and of Broersen and colleagues. The findings of Ryan et al. indicate that 10% ammonia disaggregates Aβ42 more efficiently than HFIP.

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