产品别名:4-O-Acetyl-21-O-de(aminocarbonyl)-23,24-didehydro-39,46-dinor-6-deoxo-25-deoxy-6-(2,3-dimethoxy-1-oxopropoxy)-25-oxokabiramide C
CAS号:122752-21-0
英文别名:Mycalolide B
分子量:1027.16
分子式:C52H74N4O17
纯度:≥98%
外观:见爱必信官网
保存方法:Store at -20° C
描述:Mycalolide B has been shown to inhibit actin polymerization (IC50=10-50 nM) with a different mechanism of action from cytochalasin D. It suppresses actin-activated myosin Mg2+-ATPase activity without changing myosin light chain phosphorylation resulting in inhibition of smooth muscle contractions. Mycalolide B depolymerizes F-actin at differing concentrations by nibbling and forms a 1:1 complex with G-actin. Mycalolide B, at a concentration of 3 μM, abolished both ADP (10 μM)- and collagen (3 μg/ml)-induced platelet aggregation in vitro.
应用:A novel and specific actomyosin ATPase inhibitor