描述:CGP 74514A is a cell permeable, potent, and selective inhibitor of CDK1/cyclin B (IC50 = 25 nM). CGP 74514A is reported to affect the activities of other kinases only at much higher concentrations, such as PKCα (IC50 = 6.1 μM), PKA (IC50 = 125 μM) and EGFR (IC50 > 10 μM). CGP 74514A induces mitochondrial damage and apoptosis in several human leukemia cell lines (>3μM).
应用:An inhibitor of CDK1/cyclin B, PKCα, PKA, and EGFR