描述:Apelin-13 is a 13 amino acid polypeptide encoded by the apelin gene which yields a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). Apelin-13 is an endogenous ligand of Apelin Receptor (APLNR/APJ receptor), a G protein-coupled receptor (EC50 = 370 μM), that plays important roles in regulating fluid homeostasis, cardiovascular function, and insulin sensitivity. Research has also shown that Apelin-36 blocks the entry of human immunodeficiency virus into cells. Apelin-13 is an activator of Apelin Receptor.
应用:An endogenous ligand of the G-protein coupled receptor APJ