描述:ICRF-193, a bisdioxopiperazine, is a catalytic noncleavable complex-forming inhibitor of DNA Topo II (topoisomerase II) that does not produce protein-linked DNA strand breaks. This compound has been shown to induce erythroid differentiation and apoptosis. Mechanistic studies suggest that ICRF-193 affects the caspase-3 activation/cleavage pathway of cell growth and associates with ATR-dependent inhibition of polo-like kinase (plk) 1 kinase activity and a decrease in cyclin B1 phosphorylation. ICRF-193 is an inhibitor of Topo II beta.
应用:A bisdioxopiperazine which induces apoptosis and erythroid differentiation