- ￥1648 - 2295
- 爱必信(absin)
- 上海
- abs42018484
- 2025年07月12日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Store at -20° C，2 years.
- 保质期：
2年
- 英文名：
Filipin III, filimarisin
- 库存：
现货
- 供应商：
爱必信(上海)生物科技有限公司
- CAS号：
480-49-9
- 规格：
500ug/1mg
| 规格： | 500ug | 产品价格： | ￥1648.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥2295.0 |
| 描述 | Filipin III is a pentaene macrolide antibiotic and the predominant isomer of four isomeric polyene macrolides isolated from cultures of S. filipinensis. Due to Filipin III’s ability to fluoresce and bind to cholesterol, the compound has been used to detect cholesterol in membranes through freeze fracture electron microscopy and through decreased fluorescence of Filipin III upon binding. Through Filipin III’s cholesterol sequestering activity, the compound was able to disrupt the lipid rafts in both normal and transformed keratinocytes resulting in inhibition of the AKT pathway. |
| 应用 | A cholesterol-binding, fluorescing antibiotic |
| 纯度 | >90% |
| 储存/保存方法 | Store at -20° C，2 years. |
| 别名 | 菲律宾菌素；菲律平III; filimarisin |
| 外观 | A crystalline solid |
| 可溶性/溶解性 | DMSO: 10 mg/ml |
| 参考文献 | 1. Severs, N.J., et al. 1983. Biochim. Biophys. Acta. 737: 373-408. PMID: 6349687 2. Miller, R.G. 1984. Cell Biol. Int. Rep. 8: 519-535. PMID: 6378397 3. Castanho, M.A., et al. 1992. J. Biol. Chem. 267: 204-209. PMID: 1730589 4. Bonneau, L., et al. 2010. Biochim. Biophys. Acta. 1798: 2150-2159. PMID: 20674542 5. Calay, D., et al. 2010. J. Invest. Dermatol. 130: 1136-1145. PMID: 20054340 |
分子结构图：
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