描述:ALLM (Calpain Inhibitor) is a cell-permeable, peptide aldehyde inhibitor of calpain I (Ki = 120 nM) and calpain II (Ki = 230 nM). ALLM acts as a very potent inhibitor of cathepsin L (Ki = 0.6 nM) and the strongest inhibitor of cathepsin B (Ki = 100 nM) amongst the peptide aldehydes. This compound inhibits the processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro. ALLM also inhibits other neutral cysteine proteases, and activation-induced programmed cell death. It restores defective immune responses in HIV+ donors. ALLM blocks nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. ALLM also acts as a weak inhibitor of proteasome.
应用:A cell-permeable, peptide aldehyde inhibitor of calpains and cathepsins