描述:Potent and selective GluR5-containing kainate receptor antagonist (IC50 = 7 nM) that displays selectivity over GluR6-containing kainate, NMDA, AMPA and group I mGlu receptors. Reversibly blocks induction of NMDA recptor-independent long term potentiation (LTP) in vitro at nanomolar concentrations.
应用:A potent and selective GluR5-containing kainate receptor antagonist