,SMAD3; MADH3; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3
靶点:
-
浓度:
-
应用范围:
-
宿主:
-
适应物种:
-
保质期:
-
抗原来源:
-
目录编号:
-
级别:
-
库存:
99
供应商:
爱必信(上海)生物科技有限公司
标记物:
-
克隆性:
-
保存条件:
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
形态:
-
亚型:
-
免疫原:
-
规格:
100ul
概述
别名
SMAD3; MADH3; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3
宿主
Mouse
反应种属
Human,Rat,Mouse
应用
WB: 1/500-1/1000, IHC: 1/50-1/100
分子量
Detects a band of approximately 52,60 kD(Predicted molecular weight: 52 kD) Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
免疫原
Recombinant Protein of Smad3
性能
形式
Monoclonal Antibody
纯化方法
Affinity Purified
克隆号
6F7
同种型
IgG
储存/保存方法
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
存储溶液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
修饰
Unmodified
靶标
背景说明
Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmit TGF-β signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5, and 8; the common-mediator Smad (co-Smad), Smad4; and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7 . Activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved carboxy terminal SSXS motif. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad (Smad4), allowing translocation of the complex to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses .