Detects a band of approximately 67 kD(Predicted molecular weight: 70 kD) Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
免疫原
Purified recombinant human Ku70 protein fragments expressed in E.coli.
性能
形式
Monoclonal Antibody
纯化方法
Affinity Purified
克隆号
7B1
同种型
IgG1
储存/保存方法
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
存储溶液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
修饰
Unmodified
靶标
背景说明
It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together.