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- 2025年07月16日
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- 详细信息
- 技术资料
- 抗体英文名：
,Interferon regulatory factor 5, Interferon regulatory factor 5 bone marrow variant, IRF 5, IRF-5, Irf5, IRF5_HUMAN, SLEB10,
- 库存：
99
- 供应商：
爱必信(上海)生物科技有限公司
- 保存条件：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
- 规格：
50ug/100ug
| 规格： | 50ug | 产品价格： | ￥1500.0 |
|---|---|---|---|
| 规格： | 100ug | 产品价格： | ￥2300.0 |
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抗体描述： 产品名称：Rabbit anti-IRF5 Polyclonal Antibody 产品别名：IRF5抗体 宿主：Rabbit 反应种属：Human;Mouse;Rat 克隆性：Polyclonal Antibody 保存方法：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles 产品描述：Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection (1). IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, ISGF3γ/p48, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E) (2). IRF-5 is expressed in lymphoid tissues and peripheral blood lymphocytes and participates in the induction of type I interferon genes following viral infection (3). Activation of IRF-5 signaling is triggered by the toll-like receptor (TLR) pathway, including TLR7 and MyD88 (4,5). Genetic variants of IRF-5 have been associated with disorders where the IFN pathway is abnormally activated, such as systemic lupus erythematosus (6,7). 用途范围： WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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