公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! 抗体描述: 产品名称:Rabbit anti-STK11 Polyclonal Antibody 产品别名:STK11抗体 宿主:Rabbit 反应种属:Human;Mouse;Rat 克隆性:Polyclonal Antibody 保存方法:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles 产品描述:LKB1 (STK11) is a serine/threonine kinase and tumor suppressor that helps control cell structure, apoptosis and energy homeostasis through regulation of numerous downstream kinases (1,2). A cytosolic protein complex comprised of LKB1, putative kinase STRAD, and the MO25 scaffold protein, activates both AMP-activated protein kinase (AMPK) and several AMPK-related kinases (3). AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations (4). LKB1 appears to be phosphorylated in cells at several sites, including human LKB1 at Ser31/325/428 and Thr189/336/363 (5).Mutation in the corresponding LKB1 gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands and feet (6). A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues (7). 用途范围: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000 产品信息订购:
产品货号 |
产品名称 |
规格 |
价格 |
大包装及货期 |
abs136366 |
Rabbit anti-STK11 Polyclonal Antibody |
100ug |
2300.00 |
立即咨询 |
abs136366 |
Rabbit anti-STK11 Polyclonal Antibody |
50ug |
1500.00 |
立即咨询 |
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