描述 |
The Aryl Hydrocarbon Receptor (AHR), also known as the dioxin receptor, is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AHR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). |
别名 |
AhR抗体;Ah receptor, AhR, AHR_HUMAN, Aromatic hydrocarbon receptor, Aryl hydrocarbon receptor, Aryl hydrocarbon receptor precursor, bHLHe76, Class E basic helix loop helix protein 76, Class E basic helix-loop-helix protein 76, HGNC:348, AHH, AhR repressor, AhRR, AHRR_HUMAN, aryl hydrocarbon hydroxylase regulator, aryl hydrocarbon receptor regulator, Aryl hydrocarbon receptor repressor, Arylhydrocarbon receptor repressor, bHLHe77, Class E basic helix-loop-helix protein 77, Dioxin receptor repressor, KIAA1234, MGC167813, MGC176630, OTTHUMP00000221488, OTTHUMP00000221489, |
宿主 |
Rabbit |
特异性 |
AhR Antibody detects endogenous levels of total AhR. |
反应种属 |
Human;Mouse;Rat |
预测反应种属 |
Xenopus;Chicken;Rabbit;Pig;Dog;Bovine;Sheep |
应用 |
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000 |
分子量 |
Predicted molecular weight: 96kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
免疫原 |
A synthesized peptide derived from Human AHR(Accession P35869), corresponding to amino acid residues I26-T45. |
浓度 |
1mg/ml |
纯化方法 |
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
类型 |
Polyclonal Antibody |
储存/保存方法 |
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
存储溶液 |
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
背景说明 |
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. |
组织特异性 |
Expressed in all tissues tested including blood, brain, heart, kidney, liver, lung, pancreas and skeletal muscle. |
细胞定位 |
Cytosol;Nucleus; |
UniProt |
P35869/A9YTQ3 |