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- abs100384
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
STAT1抗体
- 抗体英文名：
Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84, STAT1,STAT1
- 靶点：
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- 浓度：
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- 应用范围：
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- 宿主：
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- 适应物种：
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- 保质期：
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- 抗原来源：
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- 目录编号：
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- 级别：
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- 库存：
现货
- 供应商：
爱必信(上海)生物科技有限公司
- 标记物：
-
- 克隆性：
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- 保存条件：
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
- 形态：
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- 亚型：
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- 免疫原：
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- 规格：
50ul
| 描述 | Mouse Monoclonal Antibody (Mab) |
| 别名 | STAT1抗体;Signal transducer and activator of transcription 1-alpha/beta, Transcription factor ISGF-3 components p91/p84, STAT1,STAT1 |
| 宿主 | Mouse |
| 特异性 | Purified His-tagged STAT1 protein was used to produced this monoclonal antibody. |
| 反应种属 | Human |
| 应用 | WB~~1:1000 |
| 分子量 | Predicted molecular weight: 87kD Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| 类型 | Monoclonal Antibody |
| 克隆号 | 1141CT26.2.1 |
| 同种型 | IgG1 |
| 储存/保存方法 | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| 存储溶液 | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| 研究领域 | Cancer;Cardiovascular;Metabolism;Microbiology;Neuroscience;Signal Transduction |
| 背景说明 | Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN- stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN- gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. |
| 细胞定位 | Cytoplasm. Nucleus. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4 |
| UniProt | P42224 |
| 参考文献 | Kristensen I., et al. Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. Schindler C., et al. Proc. Natl. Acad. Sci. U.S.A. 89:7836-7839(1992). Ota T., et al. Nat. Genet. 36:40-45(2004). Bechtel S., et al. BMC Genomics 8:399-399(2007). Kalnine N., et al. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. |
STAT1 Antibody(Cat. #abs100384) western blot analysis in CEM,Hela cell line lysates (35μg/lane).This demonstrates the STAT1 antibody detected the STAT1 protein (arrow).
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文献和实验- Mammary epithelial cell derived exosomal MiR-221 mediates M1 macrophage polarization via SOCS1/STATs to promote inflammatory responseMingcheng Cai, Yu Shi, Tianhao Zheng, Shenqiang Hu, Kun Du, Anyong Ren, Xianbo Jia, Shiyi Chen, Jie Wang, Songjia Lai
International Immunopharmacology. 2020 Jun 01 .
影响因子： 3.361
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抗核抗体(anti-nucleic antibody，ANA)检测
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