Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
规格:
200 μL
产品名称:
SARM1 Rabbit pAb
货号:
A20556
背景:
NAD(+ hydrolase; which plays a key role in axonal degeneration following injury by regulating NAD(+ metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration; an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+ depletion: in response to injury; SARM1 is activated and catalyzes cleavage of NAD(+ into ADP-D-ribose (ADPR; cyclic ADPR (cADPR and nicotinamide; NAD(+ cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP(+; but not other NAD(+-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1; TRIF-dependent activation of NF-kappa-B and IRF3; and the phosphorylation of MAPK14/p38.
别名:
SARM; HsTIR; SAMD2; hSARM1; MyD88-5
宿主:
Rabbit
反应物种:
Human
验证应用:
WB; IP
免疫原:
A synthetic peptide corresponding to a sequence within amino acids 625-724 of human SARM1 (NP_055892.2).
基因ID:
23098
存储缓冲液:
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide;50% glycerol;pH7.3.