Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
规格:
50 μL
产品名称:
HAVCR2 Rabbit pAb
货号:
A20495
背景:
T cell immunoglobulin and mucin domain-3 (TIM3); also called hepatitis A virus cellular receptor 2 (HAVCR2); isa transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important rolein the Th1-mediated immune response. TIM3 is expressed on the Th1 cells; CD8 T-cells; monocytes; anddendritic cells; but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosisof apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interactionwith phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressivefunctions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with anagonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is alsoregarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as twoimportant coinhibitory regulators of T cell responses; have been implicated with the T-cell dysfunction orexhaustion associated with chronic HBV infection including HBV-related HCC.
别名:
Tim; TIM-; Tim3; Timd; TIM-3; Timd3
宿主:
Rabbit
反应物种:
Human; Mouse; Rat
验证应用:
WB
免疫原:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-193 of mouse HAVCR2 (NP_599011.2).
基因ID:
171285
存储缓冲液:
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide;50% glycerol;pH7.3.