Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
规格:
50 μL
产品名称:
TPO-R/CD110/c-Mpl Rabbit pAb
货号:
A16715
背景:
In 1990 an oncogene; v-mpl; was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue; named; c-mpl; was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl; thrombopoietin; was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene; CD110; is a 635 amino acid transmembrane domain; with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic; emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases; as well as the STAT family; the MAPK family; the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
别名:
MPL; C-MPL; CD110; MPLV; THCYT2; TPOR
宿主:
Rabbit
反应物种:
Human; Mouse; Rat
验证应用:
WB; IF
免疫原:
Recombinant fusion protein containing a sequence corresponding to amino acids 295-390 of human TPO-R/CD110/c-Mpl (NP_005364.1).
基因ID:
4352
存储缓冲液:
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide;50% glycerol;pH7.3.
图片:
Western blot - TPO-R/CD110/c-Mpl Rabbit pAb (A16715)