Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
规格:
50 μL
产品名称:
TXK Rabbit pAb
货号:
A14792
背景:
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development; function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC activate T-cell receptor (TCR; a series of phosphorylation leads to the recruitment of TXK to the cell membrane; where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways; including regulation of the actin cytoskeleton. Like ITK; can phosphorylate PLCG1; leading to its localization in lipid rafts and activation; followed by subsequent cleavage of its substrates. In turn; the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT translocates into the nucleus to perform its transcriptional duty. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with PARP1 and EEF1A1. Within the complex; phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
别名:
TXK; BTKL; PSCTK5; PTK4; RLK; TKL
宿主:
Rabbit
反应物种:
Rat
验证应用:
WB
免疫原:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human TXK (NP_003319.2).
基因ID:
7294
存储缓冲液:
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide;50% glycerol;pH7.3.