Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
规格:
50 μL
产品名称:
C9orf72 Rabbit pAb
货号:
A15970
背景:
The protein encoded by this gene plays an important role in the regulation of endosomal trafficking; and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778; 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA; and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms.
别名:
C9orf72; ALSFTD; DENNL72; FTDALS; FTDALS1
宿主:
Rabbit
反应物种:
Human; Mouse; Rat
验证应用:
WB; IHC; IF
免疫原:
Recombinant fusion protein containing a sequence corresponding to amino acids 9-200 of human C9orf72 (NP_001242983.1).
基因ID:
203228
存储缓冲液:
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide;50% glycerol;pH7.3.