Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
规格:
200 μL
产品名称:
HB-EGF Rabbit pAb
货号:
A1695
背景:
Heparin-binding EGF-like growth factor (HB-EGF) is a 12-16 kDa member of the epidermal growth factor (EGF)family. It possesses an EGF-like domain; and a heparin-binding motif. Mature HB-EGF is a soluble peptide thatarises from proteolytic processing of the transmembrane form. Human HB -EGF shows 76% and 73% aasequence identity with rat and mouse HB-EGF; respectively. It is required for normal cardiac valve formationand normal heart function; promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation; it is mitogenic for fibroblasts; but not endothelial cells. HB-EGF classified as agroup 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activityassociated with ErbB4 binding appears to be limited to non -mitogenic actions; while EGFR binding inducesboth mitogenic and non-mitogenic activity.
别名:
HBEGF; DTR; DTS; DTSF; HEGFL
宿主:
Rabbit
反应物种:
Human; Mouse; Rat
验证应用:
WB; IF
免疫原:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-160 of human HB-EGF (NP_001936.1).
基因ID:
1839
存储缓冲液:
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide;50% glycerol;pH7.3.