Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
规格:
50 μL
产品名称:
CD225/IFITM1 Rabbit pAb
货号:
A4228
背景:
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm; permitting endocytosis; but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses; including influenza A virus; SARS coronaviruses (SARS-CoV and SARS-CoV-2; Marburg virus (MARV; Ebola virus (EBOV; Dengue virus (DNV; West Nile virus (WNV; human immunodeficiency virus type 1 (HIV-1 and hepatitis C virus (HCV. Can inhibit: influenza virus hemagglutinin protein-mediated viral entry; MARV and EBOV GP1;2-mediated viral entry and SARS-CoV and SARS-CoV-2 S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Inhibits SARS-CoV-2 S protein-mediated syncytia formation. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. In hepatocytes; IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation. IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry; possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome.
别名:
IFITM1; 9-27; CD225; DSPA2a; IFI17; LEU13
宿主:
Rabbit
反应物种:
Human; Mouse
验证应用:
WB; IHC
免疫原:
A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human CD225/IFITM1 (NP_003632.3).
基因ID:
8519
存储缓冲液:
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide;50% glycerol;pH7.3.