Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
规格:
50 μL
产品名称:
PDF Rabbit pAb
货号:
A10458
背景:
Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene; peptide deformylase (PDF); removes the formyl group from the initiating methionine of nascent peptides. In eubacteria; deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF; actinonin; acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells; only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans; PDF function may therefore be restricted to rapidly growing cells.
别名:
PDF
宿主:
Rabbit
反应物种:
Human; Mouse; Rat
验证应用:
WB
免疫原:
Recombinant fusion protein containing a sequence corresponding to amino acids 40-243 of human PDF (NP_071736.1).
基因ID:
64146
存储缓冲液:
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide;50% glycerol;pH7.3.