Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
规格:
200 μL
产品名称:
TAB1 Rabbit pAb
货号:
A5749
背景:
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1; which is known to mediate various intracellular signaling pathways; such as those induced by TGF beta; interleukin 1; and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1; while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta; suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha); and thus represents an alternative activation pathway; in addition to the MAPKK pathways; which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
别名:
TAB1; 3'-Tab1; MAP3K7IP1
宿主:
Rabbit
反应物种:
Human; Mouse
验证应用:
WB; IF; IP
免疫原:
Recombinant fusion protein containing a sequence corresponding to amino acids 205-504 of human TAB1 (NP_006107.1).
基因ID:
10454
存储缓冲液:
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide;50% glycerol;pH7.3.