Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
规格:
50 μL
产品名称:
RAB3A Rabbit pAb
货号:
A5379
背景:
Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment; tethering and docking of secretory vesicles to the plasma membrane (By similarity. Upon stimulation; switches to its active GTP-bound form; cycles to vesicles and recruits effectors such as RIMS1; RIMS2; Rabphilin-3A/RPH3A; RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity. Upon GTP hydrolysis by GTPase-activating protein; dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity. Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity. Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR via the interaction with 2 effectors; SYTL4 and myosin-9/MYH9. Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1. Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity. Interacts with MADD (via uDENN domain; the GTP-bound form is preferred for interaction (By similarity.
别名:
RAB3A
宿主:
Rabbit
反应物种:
Mouse; Rat
验证应用:
WB; IF
免疫原:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RAB3A (NP_002857.1).
基因ID:
5864
存储缓冲液:
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide;50% glycerol;pH7.3.