DNA损伤试剂盒

Muse^® Multi-Color DNA Damage Kit

The Muse^® Multi-Color DNA Damage Kit – 50 Tests (Part Number: MCH200107) is designed to enable researchers to have a quick and easy way to detect the activation of ATM and H2A.X using the Guava^® Muse^® Cell Analyzer. The kit was optimized using a DNA damaging reagent, Etoposide, on HeLa cells as a model system, but can be used with other human cell lines to investigate both the physical and chemical factors that can induce a DNA damage response through the ATM-dependent signaling pathway. Data generated using the Muse System provides statistical values, measuring the:

• Percentage of negative cells (e.g., no DNA damage)
• Percentage of ATM activated cells
• Percentage of H2A.X activated cells
• Percentage of DNA double-strand breaks (dual activation of both ATM and H2A.X)

The Muse Multi-Color DNA Damage Kit includes two directly conjugated antibodies—a phospho-specific ATM (Ser1981)-PE and a phospho-specific Histone H2A.X PECy5 conjugated antibody—to measure the extent of DNA damage in testing samples. This two-color kit is designed to detect the phosphorylation state of ATM and Histone H2A.X simultaneously by flow analysis. Together, two-color analysis of ATM and Histone H2A.X activation in multiplex provides a more reliable detection method for assessing the DNA damage signaling pathway.

This antibody pair provides a sensitive and valuable tool to study the factors that induce DNA damage and affect DNA repair, allowing exploration of the relationship between DNA damage, cell cycle checkpoints, and initiation of apoptosis. Both antibodies provided in the kit are carefully titrated and optimized together to ensure exceptional performance when run in multiplex, alleviating the need for any additional optimization. This kit contains optimized fixation, permeabilization, and assay buffers to provide researchers with a complete solution for DNA damage signaling analysis.

The Muse Multi-Color DNA Damage Kit is optimized for use on the Muse System, which makes sophisticated, fluorescent-based analysis fast, easy, convenient, and affordable. Sample preparation is minimal, and after loading samples onto the Muse Cell Analyzer, the intuitive software provides detailed or summary analysis of your cell sample in a few short steps.


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其中Sigma公司是领xian的生命科学与高科技公司，其生物化学与有机化学产品、试剂盒和服务被广泛应用于染色体组和蛋白质组研究等生命科学研究、生物技术、药品开发和疾病诊断以在2015年年底，Sigma-Aldrich与默克密理博合为一体。

我公司所销售的ELISA试剂盒,品种多，质量好，灵敏度高,涉及的品牌有美国原装/分装等不同价格档次的盒子。
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