Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
规格:
50 μL
产品名称:
[KO Validated] HIF1AN/FIH1 Rabbit mAb
货号:
A3701
背景:
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD. Functions as an oxygen sensor and; under normoxic conditions; the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A; VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD of NFKB1; NFKBIA; NOTCH1; ASB4; PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2; respectively. Negatively regulates NOTCH1 activity; accelerating myogenic differentiation. Positively regulates ASB4 activity; promoting vascular differentiation.
别名:
FIH1
宿主:
Rabbit
反应物种:
Human
验证应用:
WB
免疫原:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HIF1AN/FIH1 (Q9NWT6).
基因ID:
55662
存储缓冲液:
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide;0.05% BSA;50% glycerol;pH7.3.
图片:
Western blot - [KO Validated] HIF1AN/FIH1 Rabbit mAb (A3701)
Western blot - [KO Validated] HIF1AN/FIH1 Rabbit mAb (A3701)