Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
规格:
50 μL
产品名称:
Phospho-ULK1-S638 Rabbit pAb
货号:
AP1196
背景:
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores; the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1 via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1; PRKAB2 and PRKAG1; leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy. Phosphorylates FLCN; promoting autophagy. Phosphorylates AMBRA1 in response to autophagy induction; releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation.
别名:
ULK1; ATG1; ATG1A; UNC51; Unc51.1; hATG1; ULk1
宿主:
Rabbit
反应物种:
Human; Mouse
验证应用:
WB
免疫原:
A synthetic phosphorylated peptide around S638 of human ULK1 (NP_003556.1).
基因ID:
8408
存储缓冲液:
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide;50% glycerol;pH7.3.
图片:
Western blot - Phospho-ULK1-S638 Rabbit pAb (AP1196)