Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
规格:
200 μL
产品名称:
Phospho-Cyclin E1-T77 Rabbit mAb
货号:
AP1014
背景:
The protein encoded by this gene belongs to the highly conserved cyclin family; whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2; whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors; which results in chromosome instability; and thus may contribute to tumorigenesis. This protein was found to associate with; and be involved in; the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus); which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq; Apr 2016]
别名:
CCNE; pCCNE1
宿主:
Rabbit
反应物种:
Human; Mouse
验证应用:
WB
免疫原:
A synthetic phosphorylated peptide around T77 of human Cyclin E1 (P24864).
基因ID:
898
存储缓冲液:
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide;0.05% BSA;50% glycerol;pH7.3.
图片:
Western blot - Phospho-Cyclin E1-T77 Rabbit mAb (AP1014)