Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
规格:
50 μL
产品名称:
Phospho-MAP3K5-S83 Rabbit pAb
货号:
AP0059
背景:
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK); MAPK kinase (MKK or MEK); and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase; MAPK kinase/MEK; which in turn activates MAPK. The kinases of these signaling cascades are highly conserved; and homologs exist in yeast; Drosophila; and mammalian cells. MAPKKK5 contains 1;374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1; MAPKK4) in vitro; and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
别名:
MAP3K5; ASK1; MAPKKK5; MEKK5
宿主:
Rabbit
反应物种:
Human
验证应用:
WB
免疫原:
A synthetic phosphorylated peptide around S83 of human MAP3K5 (NP_005914.1).
基因ID:
4217
存储缓冲液:
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide;50% glycerol;pH7.3.
图片:
Western blot - Phospho-MAP3K5-S83 Rabbit pAb (AP0059)