Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome; an octamer composed of pairs of each of the four core histones (H2A; H2B; H3; and H4). The chromatin fiber is further compacted through the interaction of a linker histone; H1; with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead; they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.