108-02ScienCell重组人骨形成蛋白-2rhBMP-2,Recombinant Human Bone Morphogenetic Protein-2, 2 ug,产品简介: 产品品牌:ScienCell 产品货号:108-02S 产品名称:108-02ScienCell重组人骨形成蛋白-2rhBMP-2,Recombinant Human Bone Morphogenetic Protein-2, 2 ug 产品规格:2 μg
108-02ScienCell重组人骨形成蛋白-2rhBMP-2,Recombinant Human Bone Morphogenetic Protein-2, 2 ug,产品说明: BMP(骨形态发生蛋白)属于TGF-β信号蛋白。BMP-2是一种有效的骨诱导细胞因子,能够与胶原和合成羟基磷灰石等骨传导载体联合诱导骨和软骨形成。除了其成骨活性外,BMP-2还参与器官发生,特别是心脏形态发生,以及肢体芽的形成。BMP-2表达于多种组织,包括肺、脾、脑、肝、前列腺卵巢和小肠。BMP-2的功能形式是一种26 kDa蛋白,由两条由单个二硫键连接的相同的114个氨基酸多肽链组成。每一个BMP-2单体都表达为前体多肽的C末端部分,前体多多肽还包含23个氨基酸的分泌信号序列和259个氨基酸的前肽。该前体二聚后,前肽(也是一种二硫键连接的同型二聚体)和成熟BMP-2配体之间的共价键被一种呋喃型蛋白酶裂解。
BMPs (Bone Morphogenetic Proteins) belong to the TGF-beta of signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 is also involved in organogenesis, particularly in cardiac morphogenesis, as well as limb bud formation. BMP-2 expression can be found in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine.The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease.
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