20S Proteasome-IN-4,2827061-47

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20S Proteasome-IN-4

CAS No. : 2827061-47-0

MCE 国际站：20S Proteasome-IN-4

产品活性：20S Proteasome-IN-4 (Compound 7) 是一种能透过血脑屏障的、寄生虫选择性的、具有口服活性的 20S proteasome 抑制剂，对 T. b. brucei 20S 蛋白酶体的 IC₅₀ 为 6.3 nM。20S Proteasome-IN-4 可用于非洲人类锥虫病的研究。

研究领域：Metabolic Enzyme/Protease  |  Anti-infection

作用靶点：Proteasome  |  Parasite

In Vitro: 20S Proteasome-IN-4 (Compound 7) (24 h) inhibits T. b. brucei growth with an EC₅₀ of <2.5 nM.

In Vivo: 20S Proteasome-IN-4 (Compound 7) (3 mg/kg; i.g.; once a day for 4 days) cures a stage I mouse model of human African trypanosomiasis.
20S Proteasome-IN-4 (15 mg/kg; i.g.; twice a day for 1 week) cures a stage II mouse model of human African trypanosomiasis.

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