Ifebemtinib,1227948-82-4

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Ifebemtinib

CAS No. : 1227948-82-4

MCE 国际站：Ifebemtinib

产品活性：Ifebemtinib (BI 853520) 是一种具有口服活性的粘附斑激酶 (FAK) 强效抑制剂 (重组 FAK IC₅₀=1 nM)，Ifebemtinib 表现出对癌细胞的抗增殖活性。

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：FAK

In Vitro: Ifebemtinib (BI 853520) (0-3 μM; 2 h) inhibits cancer cells growth.
Ifebemtinib (BI 853520) (0-30 μM; 4-6 d) represses tumor cell proliferation and invasion only in 3D culture.
Ifebemtinib (0-10 μM; 24 h) represses Y397-FAK autophosphorylation.
Ifebemtinib (0.1 μM; 96 h) shows a fast and potent inhibition of FAK in this highly metastatic murine breast cancer cell line.

In Vivo: Ifebemtinib (BI 853520) (oral gavage; 50 mg/kg; once daily; 0-8 weeks) treatment significantly suppresses primary tumor growth of all three cell lines in vivo.

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