Avibactam sodium dihydrate阿维巴坦

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Avibactam sodium dihydrate

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MCE 国际站：Avibactam sodium dihydrate

产品活性：Avibactam sodium (NXL-104) dihydrate 是一种共价的、可逆的非 β-内酰胺 β-内酰胺酶抑制剂 (β-lactamase) 抑制剂，抑制 β-lactamase TEM-1 和 CTX-M-15，IC₅₀ 分别为 8 nM 和 5 nM。

研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

In Vitro: Avibactam is a molecule with little antibacterial activity, that inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases.
Ceftazidime (HY-B0593)-Avibactam (0-256 mg/L) inhibits 16 bla_KPC-2 positive and 1 of bla_OXA-232 positive Klebsiella pneumonia growth with MIC₅₀ and MIC₉₀ for both 8 mg/L.

In Vivo: Ceftazidime-Avibactam (0.375 mg/g; s.c.; q8h for 10 days) has a significant effect on the bacteria and led to a certain therapeutic efficacy in K. pneumoniae strain Y8 infected mouse model.
Avibactam (64 mg/kg; s.c.; once) shows mean estimated half-life in plasma in the terminal phase of 0.24 h in Pseudomonas aeruginosa infected neutropenic mice with lung infection.

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