Ertapenem

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Ertapenem

CAS No. : 153832-46-3

MCE 国际站：Ertapenem

产品活性：Ertapenem (MK-0826) 是一种广谱的长效 β-内酰胺抗生素。Ertapenem 对多种厌氧菌具有广谱抗菌活性，其 MIC 值为 0.12 μg/mL。Ertapenem 可用于皮肤、肺、胃、骨盆和泌尿道的细菌感染相关的研究。

研究领域：Anti-infection

作用靶点：Antibiotic  |  Bacterial

In Vitro: Ertapenem (0-100 μg/mL approximately, 48 h) is active against 99.1% of all anaerobes with a mode MIC of 0.12 μg/mL and MIC₉₀ of 1 μg/mL, and MIC’s ≥8 μg/mL for B.fragilis and B.vulgatus species, respectively.

In Vivo: Ertapenem (Subcutaneous injection, 0-10 mg/kg, 0-120 h after infection, S. aureus thigh tissue infection model) shows > 3 log₁₀ CFU reduction of organism at 10 mg/kg, and maintains the activity with 3.3 and 4.4 log₁₀ CFU eliminated at 2 mg/kg.
Ertapenem (Subcutaneous injection, 4h after infection, systemic infection model) is active against all gram-positive organisms, and is also active against gram-negative organisms tested with ED₅₀s of <0.25 mg/kg/dose.

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