Cefotiam dihydrochloride hydra

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Cefotiam dihydrochloride hydrate

CAS No. :

MCE 国际站：Cefotiam dihydrochloride hydrate

产品活性：Cefotiam (SCE-963) dihydrochloride hydrate 是肠外头孢菌素类抗生素。Cefotiam dihydrochloride hydrate 对革兰氏阳性菌和革兰氏阴性菌具有广谱活性。

研究领域：Anti-infection

作用靶点：Antibiotic  |  Bacterial

In Vitro: Cefotiam (SCE-963; 0-6.25 μg/mL; 8 h) dihydrochloride hydrate has antibacterial activity with a MIC value of 1.56 μg/mL for P. mirabilis IFO 3849.
Cefotiam (0-6.25 μg/mL; 8 h) dihydrochloride hydrate has highly active against both Staph. aureus (27 strains, MIC values of 0.5-1 μg/mL) and Staph. albus (8 strains, MICs 0.25-0.5 μg/mL). All 29 strains of haemolytic streptococci, 9 strains of pneumococci and 6 strains of Streptococcus viridans with the MIC values of in the range 0.06-4 μg/mL.

In Vivo: Cefotiam (SCE-963; 12.5-800 mg/kg; i.h.; twice a day for 5 d) dihydrochloride hydrate can cure urinary tract infection with P. mirabilis in mice to reduce or complete eradicate bacteria in the bladder walls and kidneys.

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