Pheniramine非尼拉敏-d4EP杂质A；N,N-二甲

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Pheniramine

CAS No. : 86-21-5

MCE 国际站：Pheniramine

产品活性：Pheniramine (Prophenpyridamine;Tripoton) 是第一代组胺 H1 受体拮抗剂，作用于中枢神经系统 (CNS) ，产生镇静、助眠的作用。Pheniramine 也是安全、有效的局部麻醉剂，并有止痒作用。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Immunology/Inflammation  |  Apoptosis

作用靶点：Histamine Receptor  |  Apoptosis

In Vitro: Pheniramine inhibits CYP2D6, the specific P450-isozymes, to delay metabolic time and prolong antihistaminic effects.
Pheniramine inhibits Ca²⁺ influx into BC3H-1 cells by inhibiting histamine with an IC₅₀ value of 1.01 mM and regulates cellular Ca²⁺ transmembrane action.
Pheniramine (0.5, 1.0 mM; 24 h) induces cell apoptosis in human T-cell acute lymphoblastic leukemia cell lines.
Pheniramine (1 μM-1 mM; 12-48 h) inhibits cell proliferation in a time-dependent manner and shows inhibitory concentration IC₅₀s of 550 μM (CCRF-CEM cells) and 420 μM (Jurkat cells), respectively.

In Vivo: Pheniramine (1.75 μM; i.t.) exerts local anesthesia effect and results spinal block in rats.

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