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Antitumor agent-78
CAS No. : 2870703-23-2
MCE 国际站：Antitumor agent-78
产品活性：Antitumor agent-78 具有抗肿瘤活性，能抑制癌细胞的生长和迁移。Antitumor agent-78 通过抑制 GPx-4 和升高 COX2 引发铁下垂 (ferroptosis)。Antitumor agent-78 还能激活肿瘤细胞固有凋亡通路 (Bax-Bcl-2-caspase-3)，阻碍肿瘤细胞上皮间质转化 (EMT) 过程。
研究领域：Apoptosis | Immunology/Inflammation
作用靶点：Ferroptosis | Apoptosis | Bcl-2 Family | COX
In Vitro: Antitumor agent-78 (compound 2b) (30 μM; 4 h) exhibits good liposoluble and improved cellular uptake in A549 cancer cells.
Antitumor agent-78 (20 μM; 36 h) produces cytotoxicity by inducing apoptosis of A549 cancer cells.
Antitumor agent-78 (20 μM; 24 h) results in significant down-regulation of Bcl-2 and upregulation of Bax, also leads to E-cadherin increase, Vimentin decrease.
Antitumor agent-78 (20 μM; 24 h) arrests cell cycle at S phase and G2/M phase.
Antitumor agent-78 (10 μM; 12 h) inhibits cells migration with inhibition rate of 53%.
In Vivo: Antitumor agent-78 (compound 2b) (6 μg/kg; i.v.; injected on day 8, 10, 12) displays better potential antitumor activity than Oxaliplatin (HY-17371), without significant damage to kidney and liver as well as weight loss.
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