PF-06649298,1854061-16-7

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PF-06649298

CAS No. : 1854061-16-7

MCE 国际站：PF-06649298

产品活性：PF-06649298 是一个 sodium-coupled citrate transporter (NaCT or SLC13A5) 抑制剂。PF-06649298 在人类肝细胞中与 NaCT 结合从而抑制柠檬酸盐运输，其 IC₅₀ 值为 16.2 μM。PF-06649298 可用于调节糖代谢以及脂代谢的研究。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Sodium Channel

In Vitro: PF-06649298 (0-100 μM; 30 min) inhibits citrate uptaken in cells.

In Vivo: PF-06649298 (250 mg/kg; p.o. twice a day; for 21 days) reverses glucose intolerance of high fat diet (HFD) mice.

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