CDK8-IN-9,2850253-95-9

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CDK8-IN-9

CAS No. : 2850253-95-9

MCE 国际站：CDK8-IN-9

产品活性：CDK8-IN-9 (compound 22) 是一种有效的 II 型 CDK8 抑制剂, 其IC₅₀ 值为 48.6 nM。CDK8-IN-9 可以抑制肿瘤生长，用于结直肠癌研究。

研究领域：Cell Cycle/DNA Damage

作用靶点：CDK

In Vitro: CDK8-IN-9 (compound 22) (0-100 μM, 48 h) can significantly inhibit cell proliferation and target CDK8 to inhibit the activation of the WNT/β-catenin pathway, thereby suppressing β-catenin-mediated transcriptional activity of TCF/ LEF.
CDK8-IN-9 (compound 22) (0.5,1 and 2 μM, 24 h) induces G2/M and S-phase cell cycle arrest, thereby inhibiting cell proliferation rather than inducing apoptosis.

In Vivo: CDK8-IN-9 (compound 22) (p.o., 20, 40 and 80 mg/kg, daily, 3 weeks) significantly reduces in tumor volume and inhibits weight loss in mice at the concentration of 80 mg/kg in Balb/c mice infected with CT-26 murine colon cancer cells.

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