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2426665-56-5
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Tubulin polymerization-IN-13
CAS No. : 2426665-56-5
MCE 国际站：Tubulin polymerization-IN-13
产品活性：Tubulin polymerization-IN-13 (Compound 4f) 是一种微管蛋白聚集抑制剂 (IC50=0.37 μM) 。Tubulin polymerization-IN-13 表现出对癌细胞的抗增殖活性，可诱导细胞凋亡，具有潜在的抗血管活性。
研究领域：Cell Cycle/DNA Damage | Cytoskeleton | Apoptosis
作用靶点：Microtubule/Tubulin | Apoptosis
In Vitro: Tubulin polymerization-IN-13 (0.005-2.8 nM) treatment inhibits tumor cell proliferation.
Tubulin polymerization-IN-13 (8.7-10 μM) is non-toxic in non-tumor cells.
Tubulin polymerization-IN-13 (1-50 nM; 24 h) treatment induces cell cycle arrest in G2/M.
Tubulin polymerization-IN-13 (10 nM; 24 and 48 h) treatment induces cell apoptosis.
Tubulin polymerization-IN-13 (10-100 nM; 24 h) treatment induces alteration of the microtubule network.
In Vivo: Tubulin polymerization-IN-13 (intraperitoneal injection; 15 or 5 mg/kg; once every other day; 4 times) reduces tumor growth in a dose-dependent manner in an orthotopic murine tumor model.
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文献和实验SDS Gel Electrophoresis of Tubulin\MAPs
. Scan the gels or photographically analyze them. Determine the molecular weights of the proteins (tubulin and MAP's).
Large Scale Tubulin Preparation
Tubulin is purified from bovine/porcine brain by two cycles of polymerization/depolymerization followed by removal of copurifying proteins on a phosphocellulose (PC) column. The procedure described here is for a large scale prep (10 cow brains
Large Scale Tubulin Preparation
Large Scale Tubulin Preparation Tubulin is purified from bovine/porcine brain by two cycles of polymerization/depolymerization followed by removal of copurifying proteins on a phosphocellulose (PC) column. The procedure described
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