JTE-607 is an inhibitor of inflammatory cytokine synthesis.{62807} It inhibits the production of TNF-α, IL-1β, IL-6, IL-8, and IL-10 in LPS-stimulated isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 11, 5.9, 8.8, 7.3 and 9.1 nM, respec
库存:
10 mg, 25 mg, 5 mg, 50 mg
供应商:
Cayman
CAS号:
188791-09-5
A cytokine synthesis inhibitor; inhibits the production of TNF-α, IL-1β, IL-6, IL-8, and IL-10 in LPS-stimulated isolated human PBMCs (IC50s = 11, 5.9, 8.8, 7.3m and 9.1 nM, respectively); binds to CPSF3 in cell-free assays; induces accumulation of CXCL8 pre-mRNA in LPS-stimulated SC cells; reduces LPS-induced mortality in a C. parvum-sensitized mouse model of endotoxic shock from 0.3-10 mg/kg, i.v.