GLX-351322 is an inhibitor of NADPH oxidase 4 (NOX4; IC50 = 5 µM).{61052} It is selective for NOX4 over NOX2 (IC50 = 40 µM). GLX-351322 (10 µM) reduces glucose-induced production of reactive oxygen species (ROS) and cytotoxicity in isolated human pancre
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A NOX4 inhibitor (IC50 = 5 µM); selective for NOX4 over NOX2 (IC50 = 40 µM); reduces glucose-induced production of ROS and cytotoxicity in isolated human pancreatic islets at 10 µM; decreases blood glucose levels in an intravenous glucose tolerance test in mice fed a high-fat diet at an estimated 3.8 mg/kg per day