tcY-NH2 is a synthetic peptide antagonist of proteinase-activated receptor 4 (PAR4) that corresponds to amino acids 1-6 of the amino terminal tethered ligand sequence of mouse PAR4.{36396} It inhibits platelet aggregation induced by the PAR4 agonist AYP
This biochemical is available in the following size(s) 1 mg, 10 mg, 5 mg - Please inquire
A peptide antagonist of PAR4; inhibits platelet aggregation induced by AYPGKF-NH2 in washed isolated rat platelets (IC50 = 95-190 µM); induces relaxation of isolated rat aortic rings precontracted with phenylephrine and contraction of isolated rat gastric longitudinal muscle strips (EC50s = 64 and 1 µM, respectively); inhibits thrombin-induced migration of primary HCC cells at 400 µM; reduces myocardial infarct size as a percentage of the area at risk ex vivo in an isolated rat heart model of ischemia-reperfusion injury