BO-264 is a transforming acidic coiled-coil containing protein 3 (TACC3) inhibitor.{66140} It binds to TACC3 in thermal shift and drug affinity responsive target stability (DARTS) assays and inhibits the growth of JIMT-1, HCC1954, MDA-MB-231, MDA-MB-436
库存:
10 mg, 25 mg, 5 mg, 50 mg
供应商:
Cayman
CAS号:
2408648-20-2
规格:
This biochemical is available in the following size(s) 500 µg - Please inquire
A TACC3 inhibitor; binds to TACC3 in cell-free assays; inhibits the growth of JIMT-1, HCC1954, MDA-MB-231, MDA-MB-436, and CAL-51 cancer cells (IC50s = 0.19, 0.16, 0.12, 0.13, and 0.36 µM, respectively); cytotoxic to RT4 cells (IC50 = 3.66 µM); induces mitotic arrest, apoptosis, and aberrant spindle formation and reduces centrosomal localization of TACC3 in JIMT-1 cells; reduces tumor volume and increases median survival in an EMT6 mouse xenograft model at 25 mg/kg