- ￥560 - 6660
- TargetMol
- 美国
- T37791
- 2025年07月15日
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- 详细信息
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
A-971432
- 库存：
10
- 供应商：
TargetMol
- CAS号：
1240308-45-5
- 规格：
10 mg/25 mg/5 mg/1 mg
| 规格： | 10 mg | 产品价格： | ￥2950.0 |
|---|---|---|---|
| 规格： | 25 mg | 产品价格： | ￥6660.0 |
| 规格： | 5 mg | 产品价格： | ￥1620.0 |
| 规格： | 1 mg | 产品价格： | ￥560.0 |
Product Introduction
Bioactivity
英文名:A-971432
描述:A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 µM, respectively). It inhibits forskolin-induced cAMP production in CHO cells expressing S1P5 (EC50 = 4.1 nM). A-971432 (1 µM) increases electrical resistance of hCMEC/D3 cells in an in vitro blood-brain barrier model, indicating enhanced barrier integrity, and attenuates blood-brain barrier leakage in an R6/2 transgenic mouse model of Huntington’s disease when administered at a dose of 0.1 mg/kg.[1] [2] A-971432 (0.1 mg/kg per day, i.p.) decreases the number of errors made in a horizontal ladder task and increases latency to fall in the rotarod test in R6/2 mice. It also increases spontaneous alternation in the t-maze in aged mice when administered at a dose of 0.1 mg/kg.[1]
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